2,5-Biphenyldiol
Names
[ CAS No. ]:
1079-21-6
[ Name ]:
2,5-Biphenyldiol
[Synonym ]:
2,5-Dihydroxy-biphenyl
2,5-Biphenyldiol
EINECS 214-091-1
[1,1'-Biphenyl]-2,5-diol
4-hydroxy-2-phenylphenol
Biphenyl-2,5-diol
2-phenylhydroquinone
PHENYLHYDROQUINONE
MFCD00002342
2,5-Dihydroxybiphenyl
2,5-Dihydroxybiphenyl,2,5-Biphenyldiol
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
383.0±30.0 °C at 760 mmHg
[ Melting Point ]:
98-100 °C(lit.)
[ Molecular Formula ]:
C12H10O2
[ Molecular Weight ]:
186.207
[ Flash Point ]:
192.3±19.2 °C
[ Exact Mass ]:
186.068085
[ PSA ]:
40.46000
[ LogP ]:
2.09
[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C
[ Index of Refraction ]:
1.640
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DV4550000
- CHEMICAL NAME :
- 2,5-Biphenyldiol
- CAS REGISTRY NUMBER :
- 1079-21-6
- BEILSTEIN REFERENCE NO. :
- 1949429
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C12-H10-O2
- MOLECULAR WEIGHT :
- 186.22
- WISWESSER LINE NOTATION :
- QR DQ BR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1010 mg/m3/4H
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 22 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/m3/6H/2W-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea Endocrine - changes in spleen weight Endocrine - changes in thymus weight
- TYPE OF TEST :
- DNA adduct
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 259,1,1991
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
DV4550000
[ HS Code ]:
2907299090
Synthetic Route
Customs
[ HS Code ]: 2907299090
[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%
Articles
Biochem. Pharmacol. 44(6) , 1059-65, (1992)
The cytotoxic effects of phenyl-hydroquinone (PHQ) and some other hydroquinones on freshly isolated rat hepatocytes were investigated. Addition of PHQ (0.5 or 0.75 mM) to the hepatocytes elicited dose...
Tuning surface hydrophilicity/hydrophobicity of hydrocarbon proton exchange membranes (PEMs).J. Colloid. Interface Sci. 466 , 168-77, (2016)
The effect of annealing on the surface hydrophilicity of various representative classes of hydrocarbon-based proton exchange membranes (PEMs) is investigated. In all cases, a more hydrophilic membrane...
Metabolism of phenylhydroquinone by prostaglandin (H) synthase: possible implications in o-phenylphenol carcinogenesis.Carcinogenesis 12(1) , 145-9, (1991)
o-Phenylphenol (OPP) and its sodium salt sodium ortho-phenylphenate (NaOPP) are broad spectrum fungicides and antibacterial agents. Both are urinary bladder and renal carcinogens in the Fischer 344 ra...