AF 102A hydrochloride

Names

[ Name ]:
AF 102A hydrochloride

[Synonym ]:
AF 102A HCl
trans-Cevimeline Hydrochloride
AF 102A hydrochloride

Biological Activity

[Description]:

Trans-Cevimeline (AF102A) (hydrochloride), as a trans-isomer of AF102B, is a M1 selective cholinergic agonist. Trans-Cevimeline (AF102A) (hydrochloride) can be used for the research of Alzheimer's disease[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[Target]

M1[1]

[In Vivo]

AF102A (1 mg/kg; i.p.) reverses cognitive impairments in a step-through passive avoidance task[1]. Animal Model: Rats[1] Dosage: 1 mg/kg Administration: I.p. Result: Reversed cognitive impairments in a step-through passive avoidance task.

[References]

[1]. Fisher A, et al. (+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. J Pharmacol Exp Ther. 1991;257(1):392-403.

Chemical & Physical Properties

[ Boiling Point ]:
308.5ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₈ClNOS

[ Molecular Weight ]:
235.77400

[ Flash Point ]:
140.4ºC

[ Exact Mass ]:
235.08000

[ PSA ]:
37.77000

[ LogP ]:
2.30010

[ Vapour Pressure ]:
0.000676mmHg at 25°C

Related Compounds

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