3-Acetyl-1-propanol
Names
[ CAS No. ]:
1071-73-4
[ Name ]:
3-Acetyl-1-propanol
[Synonym ]:
2-Pentanone, 5-hydroxy-
EINECS 213-994-8
γ-Acetopropanol
MFCD00002961
5-hydroxypentan-2-one
γ-Acetylpropyl alcohol
5-Hydroxy-2-pentanone
γ-Acetopropyl alcohol
3-Acetyl-1-propanol
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
204.0±23.0 °C at 760 mmHg
[ Molecular Formula ]:
C5H10O2
[ Molecular Weight ]:
102.132
[ Flash Point ]:
93.3±0.0 °C
[ Exact Mass ]:
102.068077
[ PSA ]:
37.30000
[ LogP ]:
-0.57
[ Vapour Pressure ]:
0.1±0.9 mmHg at 25°C
[ Index of Refraction ]:
1.421
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UA4600000
- CHEMICAL NAME :
- Propanol, 3-acetyl-
- CAS REGISTRY NUMBER :
- 1071-73-4
- BEILSTEIN REFERENCE NO. :
- 1740387
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C5-H10-O2
- MOLECULAR WEIGHT :
- 102.15
- WISWESSER LINE NOTATION :
- Q3V1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6400 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - excitement Vascular - other changes
- REFERENCE :
- TNICS* Toxicology of New Industrial Chemical Substances. English translation of TPKVAL. (USSR Academy of Medical Sciences, Meditsina, Moscow, USSR) Volume(issue)/page/year: 13,118,1973
- TYPE OF TEST :
- LC - Lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TNICS* Toxicology of New Industrial Chemical Substances. English translation of TPKVAL. (USSR Academy of Medical Sciences, Meditsina, Moscow, USSR) Volume(issue)/page/year: 13,118,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1960 mg/kg
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), diffuse Gastrointestinal - other changes
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(8),103,1978
- TYPE OF TEST :
- LC - Lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TNICS* Toxicology of New Industrial Chemical Substances. English translation of TPKVAL. (USSR Academy of Medical Sciences, Meditsina, Moscow, USSR) Volume(issue)/page/year: 13,118,1973
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3500 mg/kg
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), diffuse Gastrointestinal - other changes
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(8),103,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 2260 mg/kg
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), diffuse Gastrointestinal - other changes
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(8),103,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 231 mg/m3/17W-I
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS Liver - liver function tests impaired Kidney, Ureter, Bladder - other changes in urine composition
- REFERENCE :
- TNICS* Toxicology of New Industrial Chemical Substances. English translation of TPKVAL. (USSR Academy of Medical Sciences, Meditsina, Moscow, USSR) Volume(issue)/page/year: 13,118,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 6370 mg/kg/26W-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(8),103,1978 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S37/39-S26
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
UA4600000
[ HS Code ]:
2914400090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2914400090
[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
Articles
Gig. Sanit. (9) , 4-5, (1993)
Toxic properties of acetopropyl alcohol were studied. Symptoms of CNS damages predominated in toxicodynamics. A maximal single concentration is 0.2 mg/m3 (4th class of danger).