Quercetin pentaacetate

Names

[ Name ]:
Quercetin pentaacetate

[Synonym ]:
Quercetin acetate
penta-O-acetylquercetin
Pentaacetylquercetin
quercetin pentaacetate
3,3',4',5,7-Pentahydroxyflavone pentaacetate
3,3',4',5,7-Pentaacetoxyflavone
FLAVONE,3,3',4',5,7-PENTAHYDROXY-,PENTAACETATE
quercetin peracetate

Biological Activity

[Description]:

Quercetin pentaacetate could interact with F-protein with lower binding energy and better stability to block viral adhesion. Quercetin pentaacetate interacts with RSV and inhibit the viral adhesion on cell surface[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> RSV

Research Areas >> Inflammation/Immunology

[In Vitro]

Quercetin pentaacetate (0-40 μM) shows the obvious inhibition on LPS-induced PGE2 production and COX-2 gene expression and the inhibition in NLA/LPS or L-NAME/LPS co-treated RAW 264.7 cells[2].

[References]

[1]. Bruno Rafael Pereira Lopes, et al. Quercetin Pentaacetate Inhibits in Vitro Human Respiratory Syncytial Virus Adhesion. Virus Res. 2020 Jan 15;276:197805.

[2]. Y C Chen, et al. Inhibition of Nitric Oxide Synthase Inhibitors and Lipopolysaccharide Induced Inducible NOS and cyclooxygenase-2 Gene Expressions by Rutin, Quercetin, and Quercetin Pentaacetate in RAW 264.7 Macrophages. J Cell Biochem. 2001;82(4):537-48.

Chemical & Physical Properties

[ Density]:
1.45g/cm3

[ Boiling Point ]:
666.4ºC at 760 mmHg

[ Molecular Formula ]:
C₂₅H₂₀O₁₂

[ Molecular Weight ]:
512.41900

[ Flash Point ]:
284.7ºC

[ Exact Mass ]:
512.09500

[ PSA ]:
161.71000

[ LogP ]:
3.08650

[ Vapour Pressure ]:
1.27E-17mmHg at 25°C

[ Index of Refraction ]:
1.6

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK8985000

CHEMICAL NAME :: Flavone, 3,3',4',5,7-pentahydroxy-, pentaacetate

CAS REGISTRY NUMBER :: 1064-06-8

BEILSTEIN REFERENCE NO. :: 0380215

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C25-H20-O12

MOLECULAR WEIGHT :: 512.45

WISWESSER LINE NOTATION :: T66 BO EVJ CR COV1 DOV1& DOV1 GOV1 IOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 5 ug/plate

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 197,577,1977

Safety Information

[ HS Code ]:
2915900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%