Desvenlafaxine-d6

Names

[ Name ]:
Desvenlafaxine-d6

[Synonym ]:
d6-O-desmethylvenlafaxine
8|A,9-Dihydroelymoclavine
8alpha,9-Dihydroelymoclavine
trans-dihydrolysergol
D,L-O-Desmethyl Venlafaxine-d6
d6-4-[2-dimethylamino-1-(1-hydroxycyclohexyl)-ethyl]-phenol
dihydrolysergol
9,10-Dihydrolysergol
|A-Dihydrolysergol
Dihydrolysergol I
6-Methyl-ergoline-8-methanol

Biological Activity

[Description]:

Desvenlafaxine-d6 is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Deecher, D.C., et al., Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther, 2006. 318(2): p. 657-65.

[3]. Sopko, M.A., Jr., M.J. Ehret, and M. Grgas, Desvenlafaxine: another "me too" drug? Ann Pharmacother, 2008. 42(10): p. 1439-46.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₉D₆NO₂

[ Molecular Weight ]:
269.41

[ Exact Mass ]:
269.22600

[ PSA ]:
43.70000

[ LogP ]:
2.73260

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

Related Compounds

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