mTOR inhibitor WYE-28

Names

[ CAS No. ]:
1062172-60-4

[ Name ]:
mTOR inhibitor WYE-28

Biological Activity

[Description]:

mTOR inhibitor WYE-28 (compound 28) is a selective inhibitor of mTOR>/b< (IC50)=0.08 nM. mTOR inhibitor WYE-28 inhibits PI3Kα with an IC50 value of 6 nM. mTOR inhibitor WYE-28 shows a metabolic time (T1/2) in nude mouse microsomes of 13 min[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Research Areas >> Cancer

[References]

[1]. Zask A, et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6.  

Chemical & Physical Properties

[ Molecular Formula ]:
C30H34N8O5

[ Molecular Weight ]:
586.64

Related Compounds

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