2-(3,4-Dihydroxyphenyl)ethanol

Names

[ Name ]:
2-(3,4-Dihydroxyphenyl)ethanol

[Synonym ]:
Hydroxytyrosol
4-(2-Hydroxyethyl)-1,2-benzenediol
4-(2-hydroxyethyl)benzene-1,2-diol
3,4-Dihydroxyphenylethanol
MFCD01320529
3,4-Dihydroxyphenethylalcohol
3,4-Dihydroxyphenethyl Alcohol
1,2-Benzenediol, 4-(2-hydroxyethyl)-
2-(3,4-Dihydroxyphenyl)ethanol
2-(3,4-Dihydroxyphenyl)ethyl Alcohol

Biological Activity

[Description]:

Hydroxytyrosol (DOPET) is a phenolic compound drawn from the olive tree and its leaves with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Hydroxytyrosol (DOPET) shows the inhibition of pro-inflammatory cytokines (TNF-α) and reduces the expression of cyclooxygenase-2 and inducible nitric oxide synthase (iNOS) more than 60%[1]. Hydroxytyrosol (DOPET) modulates the transcription factor NF-κB[1]. Hydroxytyrosol (DOPET) arrests the cell cycle, producing differentiation, apoptosis, or preventing DNA from oxidative stress[1].

[References]

[1]. Vilaplana-Pérez C, et al. Hydroxytyrosol and potential uses in cardiovascular diseases, cancer, and AIDS. Front Nutr. 2014 Oct 27;1:18.

[2]. Martínez L, et al. Hydroxytyrosol: Health Benefits and Use as Functional Ingredient in Meat. Medicines (Basel). 2018 Jan 23;5(1).

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
355.4±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₁₀O₃

[ Molecular Weight ]:
154.163

[ Flash Point ]:
182.6±18.3 °C

[ Exact Mass ]:
154.062988

[ PSA ]:
60.69000

[ LogP ]:
0.02

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.623

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2907299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2907299090

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Articles

Bioconversion of oleuropein to hydroxytyrosol by lactic acid bacteria.

World J. Microbiol. Biotechnol. 28(6) , 2435-40, (2012)

The aim of this work is to study the conversion of oleuropein-a polyphenol present in olives and olive oil by-products-into hydroxytyrosol, a polyphenol with antioxidant and antibacterial properties. ...

Factors influencing phenolic compounds in table olives (Olea europaea).

J. Agric. Food Chem. 60(29) , 7081-95, (2012)

The Mediterranean diet appears to be associated with a reduced risk of several chronic diseases including cancer and cardiovascular and Alzheimer's diseases. Olive products (mainly olive oil and table...

Identification of the factors responsible for the in vitro pro-oxidant and cytotoxic activities of the olive polyphenols oleuropein and hydroxytyrosol.

Cancer Lett. 330(1) , 113-21, (2013)

The olive polyphenols oleuropein and hydroxytyrosol were reported recently to produce extracellular hydrogen peroxide (H2O2) under standard culture conditions. The precise factors responsible for this...

Related Compounds

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