clinafloxacin hydrochloride

Names

[ Name ]:
clinafloxacin hydrochloride

[Synonym ]:
7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid,hydrochloride
7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride (1:1)
7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride (1:1)
3-Quinolinecarboxylic acid, 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, hydrochloride (1:1)
Clinafloxacin HCl
clinafloxacin hydrochloride

Biological Activity

[Description]:

Clinafloxacin hydrochloride (AM 1091 hydrochloride) is a potent and broad-spectrum fluoroquinolone antibiotic, with activity against gram-positive, gram-negative, and anaerobic pathogens in vitro. Clinafloxacin exhibits activity against S. pneumonia with an MIC of 1μg/ml for the parC-gyrA mutants[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

MIC: 1μg/ml (parC-gyrA mutants,S. pneumonia)[1]

[References]

[1]. Pan, X.S. and L.M. Fisher, DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae. Antimicrob Agents Chemother, 1998. 42(11): p. 2810-6.

[2]. Jorgensen, J.H., et al., Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother, 2000. 44(11): p. 2962-8.

Chemical & Physical Properties

[ Density]:
1.573 g/cm3

[ Boiling Point ]:
592.3ºCat 760 mmHg

[ Melting Point ]:
162-168°C

[ Molecular Formula ]:
C₁₇H₁₈Cl₂FN₃O₃

[ Molecular Weight ]:
402.247

[ Flash Point ]:
312ºC

[ Exact Mass ]:
401.070923

[ PSA ]:
88.56000

[ LogP ]:
3.93180

[ Storage condition ]:
Refrigerator

Related Compounds

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