N-Boc-O-tosyl hydroxylamine

Names

[ Name ]:
N-Boc-O-tosyl hydroxylamine

[Synonym ]:
TERT-BUTYL TOSYLOXYCARBAMATE
N-Boc-O-tosyl-hydroxylamine
Boc N-tosyloxycarbamate
tert-Butyl N-Tosyloxycarbamate

Biological Activity

[Description]:

N-Boc-O-tosyl hydroxylamine is used as a linker for antibody-drug conjugates (ADC)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Alkyl/ether

[References]

[1]. BOGER, Dale. CHIMER CONTAINING A TARGETING PORTION LINKED TO A SCISSION-ACTIVATED DUOCARMYCIN-TYPE PRODRUG. WO2009064913A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₇NO₅S

[ Molecular Weight ]:
287.33200

[ Exact Mass ]:
287.08300

[ PSA ]:
93.57000

[ LogP ]:
3.42520

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H317-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Baburaj, T.; et. al.

Synlett , 1993-1996, (2011)

Related Compounds

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