α,β-Methylene-ATP dilithium

Names

[ Name ]:
α,β-Methylene-ATP dilithium

[Synonym ]:
lithium,[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]methyl-hydroxyphosphoryl] hydrogen phosphate

Biological Activity

[Description]:

α,β-Methylene ATP dilithium, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand[1]. α,β-Methylene ATP dilithium is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7[2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor

[References]

[1]. Arribas-Blázquez M, et al. Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. Int J Mol Sci. 2019 Jan 3;20(1).

[2]. Claudio Coddou, et al. Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev. 2011 Sep;63(3):641-83

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₈Li₂N₅O₁₂P₃

[ Molecular Weight ]:
519.09

[ Exact Mass ]:
511.02500

[ PSA ]:
302.16000

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
22-26-36

[ RIDADR ]:
NONH for all modes of transport

Articles

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Stem Cells Dev. 22(10) , 1506-21, (2013)

Human embryonic stem cell-derived neural precursors (hESC NPs) are considered to be a promising tool for cell-based therapy in central nervous system injuries and neurodegenerative diseases. The Ca(2+...

Is there a basis for distinguishing two types of P2-purinoceptor?

Gen. Pharmacol. 16 , 433, (1985)

It is suggested that the P2-purinoceptor may be separated into two subtypes largely on the basis of the rank order of agonist potency of structural analogues of ATP and also on the activity of antagon...

The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by alpha, beta-methylene adenosine 5'-triphosphate.

Br. J. Pharmacol. 112 , 282, (1994)

1. We have previously found that the P2x-purinoceptor agonist, alpha, beta-methylene adenosine 5'-triphosphate (alpha, beta-methylene ATP), depolarizes the rat cervical vagus nerve, measured with a 'g...