α,β-Methylene-ATP

Names

[ CAS No. ]:
7292-42-4

[ Name ]:
α,β-Methylene-ATP

[Synonym ]:
Adenosine 5'-[[hydroxy(phosphonooxy)phosphinyl]methyl] phosphonate
Einecs 230-723-9
α,β-Methyleneadenosine 5'-triphosphate trisodium salt
adenosine 5'-[hydrogen [[hydroxy(phosphonooxy)phosphinyl]methyl]phosphonate]
Adenosine-5'-methylenediphosphono-P2-phosphate
5'-(Hydrogen((hydroxy(phosphonooxy)phosphinyl)methyl)phosphonate)adenosine
α,β-Methyleneadenosine5'-triphosphatetrisodiumsalt
Adenosine 5'-[[[hydroxy(phosphonooxy)phosphinyl]methyl] phosphonate]
(α,β-Methylene)adenosine triphosphate

Biological Activity

[Description]:

α,β-Methylene ATP, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand. α,β-Methylene ATP is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor

[References]

[1]. Arribas-Blázquez M, et al. Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. Int J Mol Sci. 2019 Jan 3;20(1).  

[2]. Claudio Coddou, et al. Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev. 2011 Sep;63(3):641-83  

Chemical & Physical Properties

[ Density]:
2.5g/cm3

[ Boiling Point ]:
968.2ºC at 760 mmHg

[ Molecular Formula ]:
C11H18N5O12P3

[ Molecular Weight ]:
505.20800

[ Flash Point ]:
539.3ºC

[ Exact Mass ]:
505.01600

[ PSA ]:
299.33000

[ Index of Refraction ]:
1.887

Related Compounds