N-Demethyl Mifepristone

Names

[ Name ]:
N-Demethyl Mifepristone

[Synonym ]:
(8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-11-[4-(methylamino)phenyl]-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

Biological Activity

[Description]:

N-Demethyl Mifepristone (RU 42633) is an active metabolite of Mifepristone (HY-13683). The affinities of N-Demethyl Mifepristone to the glucocorticoid receptor is 61% compared with 100% for Mifepristone[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

[References]

[1]. Nguyen D, et al. Effects of Ketoconazole on the Pharmacokinetics of Mifepristone, a Competitive Glucocorticoid Receptor Antagonist, in Healthy Men. Adv Ther. 2017 Oct;34(10):2371-2385.

Chemical & Physical Properties

[ Density]:
1.19g/cm3

[ Boiling Point ]:
628.9ºC at 760mmHg

[ Molecular Formula ]:
C₂₈H₃₃NO₂

[ Molecular Weight ]:
415.56700

[ Flash Point ]:
334.1ºC

[ Exact Mass ]:
415.25100

[ PSA ]:
49.33000

[ LogP ]:
5.45520

[ Vapour Pressure ]:
1.11E-16mmHg at 25°C

[ Index of Refraction ]:
1.625

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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