Sepimostat dimethanesulfonate

Names

[ Name ]:
Sepimostat dimethanesulfonate

[Synonym ]:
6-amidino-2-naphthyl 4-<(4,5-dihydro-1H-imidazol-2-yl)amino>benzoate methanesulfonate
6-amidino-2-naphthyl 4-(2-imidazolinyl)amino-benzoate dimethanesulfonate
6-Amidino-2-naphthyl 4-<(4,5-dihydro-1H-imidazol-2-yl)amino>benzoate dimethanesulfonate
6a-methylhexahydro-2,6-methano-2H-cyclopenta<D>furan
6'-amidino-2'-naphthyl-(4-(4,5-dihydro-1H-2-imidazolyl)amino)benzoate dimethanesulfonate

Biological Activity

[Description]:

Sepimostat dimethanesulfonate (FUT-187) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7 µM[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[In Vivo]

Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect[1]. Animal Model: Male Sprague Dawley rats weighing 150-300 g[1]. Dosage: Intravitreal injection. Administration: 1 to 100 nmol/eye. Result: Exhibited neuroprotective effects significantly.

[References]

[1]. Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409.

Chemical & Physical Properties

[ Boiling Point ]:
607.4ºC at 760mmHg

[ Molecular Formula ]:
C₂₃H₂₇N₅O₈S₂

[ Molecular Weight ]:
565.61900

[ Flash Point ]:
321.2ºC

[ Exact Mass ]:
565.13000

[ PSA ]:
238.09000

[ LogP ]:
4.52120

[ Vapour Pressure ]:
1.06E-14mmHg at 25°C

[ Storage condition ]:
2-8°C

Related Compounds

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