Sepimostat

Names

[ Name ]:
Sepimostat

[Synonym ]:
UNII-5ZFR16F4QQ
Sepimostat [INN]
Sepimostat

Biological Activity

[Description]:

Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat inhibits the Ifenprodil binding with a Ki value of 27.7 µM[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[In Vivo]

Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect[1]. Animal Model: Male Sprague Dawley rats weighing 150-300 g[1]. Dosage: Intravitreal injection. Administration: 1 to 100 nmol/eye. Result: Exhibited neuroprotective effects significantly.

[References]

[1]. Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409.

Chemical & Physical Properties

[ Density]:
1.39g/cm3

[ Boiling Point ]:
607.4ºC at 760mmHg

[ Molecular Formula ]:
C₂₁H₁₉N₅O₂

[ Molecular Weight ]:
373.40800

[ Flash Point ]:
321.2ºC

[ Exact Mass ]:
373.15400

[ PSA ]:
112.59000

[ LogP ]:
3.35160

[ Vapour Pressure ]:
1.06E-14mmHg at 25°C

[ Index of Refraction ]:
1.707

Related Compounds

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