Sumatriptan hydrochloride

Names

[ CAS No. ]:
103628-62-2

[ Name ]:
Sumatriptan hydrochloride

Biological Activity

[Description]:

Sumatriptan (GR 43175) hydrochloride is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan hydrochloride can be used for migraine headache research[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT1D Receptor:17 nM (Ki)

5-HT1B Receptor:27 nM (Ki)

5-HT1A Receptor:100 nM (Ki)


[References]

[1]. S J Peroutka, et al. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. Eur J Pharmacol. 1989 Apr 12;163(1):133-6.

[2]. K L Dechant, et al. Sumatriptan. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs. 1992 May;43(5):776-98.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H22ClN3O2S

[ Molecular Weight ]:
331.86

Related Compounds