H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 trifluoroacetate salt (Disulfide bond)

Names

[ Name ]:
H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 trifluoroacetate salt (Disulfide bond)

[Synonym ]:
DPHE-CYS-TYR-DTRP-ORN-THR-PEN-THR-OL
NTB
D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-amide
M.W. 1062.26 C50H67N11O11S2
D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2
CYS2,TYR3,ORN5,PEN7-AMIDE
threoninamide
D-Phe-Cys-Tyr-D-Trp-Orn-Pen-Thr-NH2
[Cys2, Tyr3, Orn5, Pen7]-Somatostatin 14 (7-14), amide

Biological Activity

[Description]:

CTOP is a peptide that acts as a μ-opioid receptor antagonist.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Neurological Disease

Chemical & Physical Properties

[ Density]:
1.42g/cm3

[ Boiling Point ]:
1491.2ºC at 760mmHg

[ Molecular Formula ]:
C₅₀H₆₇N₁₁O₁₁S₂

[ Molecular Weight ]:
1062.26000

[ Flash Point ]:
855.7ºC

[ Exact Mass ]:
1061.45000

[ PSA ]:
425.91000

[ LogP ]:
3.30840

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.68

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Activation of mu or delta opioid receptors in the lumbosacral spinal cord is essential for ejaculatory reflexes in male rats.

PLoS ONE 10(3) , e0121130, (2015)

Ejaculation is controlled by a spinal ejaculation generator located in the lumbosacral spinal cord, consisting in male rats of lumbar spinothalamic (LSt) cells and their inter-spinal projections to au...

Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.

J. Neurosci. 35 , 9580-94, (2015)

Due to its distinct pharmacological profile and lower incidence of adverse events compared with other opioids, buprenorphine is considered a safe option for pain and substitution therapy. However, des...

Synaptic upregulation and superadditive interaction of dopamine D2- and μ-opioid receptors after peripheral nerve injury.

Pain 155(12) , 2526-33, (2014)

A sound strategy for improving the clinical efficacy of opioids involves exploiting positive interactions with drugs directed at other targets in pain pathways. The current study investigated the role...