SRI 37892

Names

[ Name ]:
SRI 37892

Biological Activity

[Description]:

SRI 37892 (SRI37892) is a novel potent, small molecule Frizzled 7 (Fzd 7) inhibitor with IC50 of 0.66 uM in Wnt/β-catenin assay; also displays potent activity against Wnt/β-catenin signaling in LRP6-expressing HEK293 cells with IC50 of 0.78 uM, demonstrates potent activity against breast cancer HS578T and BT549 cell proliferation with IC50 of 2.2 and 1.9 uM, respectively; targets Fzd7 transmembrane domain (TMD) and bolcks Wnt/Fzd7 signaling.

[References]

References 1. Zhang W, et al. Oncotarget. 2017 Sep 6;8(53):91459-91470. View Related Products by Target Frizzled

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₁₉N₅O₂S

[ Molecular Weight ]:
465.531

Related Compounds

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