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SC-10

Names

[ CAS No. ]:
102649-79-6

[ Name ]:
SC-10

[Synonym ]:
sc-10

Biological Activity

[Description]:

SC-10 is a direct activator of PKC[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC
Research Areas >> Cancer
Signaling Pathways >> TGF-beta/Smad >> PKC

[In Vitro]

SC-10在白血病原始细胞上表现出适度的生物学效应，但不能增强这些细胞对细胞毒性药物的凋亡反应[1]。 SC-10抑制了Ara-C引起的凋亡反应[1]。

[References]

[1]. Gerold Meinhardt, et al. Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells. Anticancer Drugs. 2002 Aug;13(7):725-33.  

Chemical & Physical Properties

[ Density]:
1.192g/cm3

[ Boiling Point ]:
483.2ºC at 760 mmHg

[ Molecular Formula ]:
C17H22ClNO2S

[ Molecular Weight ]:
339.88

[ Flash Point ]:
246ºC

[ Exact Mass ]:
339.10600

[ PSA ]:
54.55000

[ LogP ]:
6.21360

[ Vapour Pressure ]:
1.72E-09mmHg at 25°C

[ Index of Refraction ]:
1.573

Related Compounds