2-Methylamino-5-chlorobenzophenone

Names

[ Name ]:
2-Methylamino-5-chlorobenzophenone

[Synonym ]:
Ro 5-4365
2-METHYLAMINO-5-CHLORO BENZOPHENONE
Methyl-aMino ketone
2-Methylamino-5-chlorobenzophenone
Benzophenone,2-acetamido-5-chloro
EINECS 213-822-1
Methanone, [5-chloro-2-(methylamino)phenyl]phenyl-
Diazepam,acid hydrolyzed
Diazepam benzophenone
[5-Chloro-2-(methylamino)phenyl](phenyl)methanone
(5-Chloro-2-(methylamino)phenyl)(phenyl)methanone
5-chloro-2-methylaminobenzophenone
TeMazepaM IMpurity A
MFCD00008284
5-Chloro-2-(Methylamino)Benzophenone
Benzophenone, 2-methylamino-5-chloro-

Biological Activity

[Description]:

(5-Chloro-2-(methylamino)phenyl)(phenyl)methanone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

2-甲氨基-5-氯苯甲酮是二苯甲酮类的分析标准品。1,2,3 2-甲氨基-5-氯苯甲酮是地西泮的代谢物，也被用作合成地西泮的合成中间体。在缴获的依替唑仑样品中发现了它本产品用于研究和法医应用。

[References]

[1]. Jain, R.Simplified method for simultaneous determination of diazepam and its metabolites in urine by thin-layer chromatography and direct densitometryJ . Chromatogr .615(2)365-368(1993).

[2]. OlguÍn, HJ, GuzmÁn, DC, GarcÍa, EH, et al.Diazepam: Principal indications related with its molecular actions and advantagesDiazepam59-80(2014).

[3]. Downey, C. , O'Donnell, A., McLaughlin, G., et al.An unusual detection of 2-amino-3-(2-chlorobenzoyl)-5-ethylthiophene and 2-methylamino-5-chlorobenzophenone in illicit yellow etizolam tablets marked " 5617" seized in the Republic of Ireland Drug Test. Anal. (2021).

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
421.9±35.0 °C at 760 mmHg

[ Melting Point ]:
93-95 °C(lit.)

[ Molecular Formula ]:
C₁₄H₁₂ClNO

[ Molecular Weight ]:
245.71

[ Flash Point ]:
209.0±25.9 °C

[ Exact Mass ]:
245.060745

[ PSA ]:
29.10000

[ LogP ]:
4.66

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.627

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ0414000

CHEMICAL NAME :: Benzophenone, 5-chloro-2-(methylamino)-

CAS REGISTRY NUMBER :: 1022-13-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C14-H12-Cl-N-O

MOLECULAR WEIGHT :: 245.72

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DJ0414000

[ HS Code ]:
2922399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922399090

[ Summary ]:
2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Determination of hydrazine in pharmaceuticals IV: Hydrazine and benzylhydrazine in isocarboxazid.

J. Pharm. Sci. 74(1) , 105-7, (1985)

A GC procedure for the simultaneous determination of hydrazine and benzylhydrazine in isocarboxazid raw material and tablet formulations has been developed. The method is based on the reaction of benz...

[The preservability of sibazon breakdown products in the cadavers of experimental animals].

Sud. Med. Ekspert. 41(3) , 24-6, (1998)

Cibasone degradation products were measured in corpses of 15 cats poisoned with cibasone in a dose of 750 mg/kg. Cibasone was assessed by semiquantitative method on Silufol UV-254 plates from the cont...

Simplified method for simultaneous determination of diazepam and its metabolites in urine by thin-layer chromatography and direct densitometry.

J. Chromatogr. A. 615(2) , 365-8, (1993)

A direct densitometric method for determination of diazepam and its metabolites in urine was developed. The proposed procedure involves acid hydrolysis of urine specimens, thereby converting diazepam ...