Cephaloridine hydrate

Names

[ CAS No. ]:
102039-86-1

[ Name ]:
Cephaloridine hydrate

[Synonym ]:
Cephaloridine hydrate

Biological Activity

[Description]:

Cephaloridine hydrate is a broad-spectrum antibacterial antibiotic. Cephaloridine has certain dose-related nephrotoxicity[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Cephaloridine hydrate 可抑制金黄色葡萄球菌青霉素敏感菌株、青霉素耐药菌株、化脓性链球菌、肺炎链球菌、白喉棒状杆菌等，MIC 为 0.05-1 μg/mL[1]。

[In Vivo]

Cephaloridine hydrate (50-500 mg/kg; 肌肉注射) 在兔和猴子中表现出剂量相关的肾毒性[2]。

[References]

[1]. P. W. Muggleton, et al. Laboratory Evaluation of a New Antibiotic-Cephaloridine (Ceporin). Br Med J. 1964 Nov 14;2(5419):1234-7.

[2]. Perkins RL, et al. Cephaloridine and cephalothin: comparative studies of potential nephrotoxicity. J Lab Clin Med. 1968 Jan;71(1):75-84.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₉N₃O₅S₂

[ Molecular Weight ]:
433.50100

[ Exact Mass ]:
433.07700

[ PSA ]:
156.19000

Related Compounds

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