aristolochic acid sodium salt

Names

[ Name ]:
aristolochic acid sodium salt

[Synonym ]:
EINECS 233-463-4
sodium,8-methoxy-6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylate

Biological Activity

[Description]:

Aristolochic acid sodium salt (Sodium aristolate 1) is a component of some Chinese herbal medicines and is responsible for nephrotoxicity. It is a prodrug that is activated by reduction of nitro groups to amines, resulting in the formation of cytotoxic DNA adducts.

[Related Catalog]:

Research Areas >> Others

Chemical & Physical Properties

[ Boiling Point ]:
615.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₀NNaO₇

[ Molecular Weight ]:
363.25400

[ Flash Point ]:
326ºC

[ Exact Mass ]:
363.03500

[ PSA ]:
113.64000

[ LogP ]:
2.52520

[ Vapour Pressure ]:
5.24E-16mmHg at 25°C

[ Water Solubility ]:
H2O: 50 mg/mL

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311 + H331-H351

[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P261-P280-P302 + P352 + P312-P304 + P340 + P312-P403 + P233

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T

[ Risk Phrases ]:
R23/24/25

[ Safety Phrases ]:
S22;S45;S36/S37/S39

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
3

[ RTECS ]:
SF8281000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Articles

Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3- and p53-dependent fibrotic responses.

J. Pathol. 236 , 421-32, (2015)

Deregulation of the tumour suppressor PTEN occurs in lung and skin fibrosis and diabetic and ischaemic renal injury. However, the potential role of PTEN and associated mechanisms in the progression of...

Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons.

Proc. Natl. Acad. Sci. U. S. A. 107 , 8440-5, (2010)

Mammalian sweet, bitter, and umami taste is mediated by a single transduction pathway that includes a phospholipase C (PLC)beta and one cation channel, TRPM5. However, in insects such as the fruit fly...