7-Deaza-2′-deoxyguanosine 5′-triphosphate

Names

[ Name ]:
7-Deaza-2′-deoxyguanosine 5′-triphosphate

[Synonym ]:
7-Deaza-2 inverted exclamation marka-deoxyguanosine 5 inverted exclamation marka-triphosphate lithium salt
7-Deaza-dGTP

Biological Activity

[Description]:

7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, is a telomerase inhibitor (IC50: 11 μM)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Telomerase

[References]

[1]. Fletcher TM, et al. Human telomerase inhibition by 7-deaza-2'-deoxypurine nucleoside triphosphates. Biochemistry. 1996 Dec 10;35(49):15611-7.

Chemical & Physical Properties

[ Density]:
2.48 g/cm3

[ Boiling Point ]:
907.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₆LiN₄O₁₃P₃

[ Molecular Weight ]:
512.12600

[ Flash Point ]:
502.4ºC

[ Exact Mass ]:
512.00900

[ PSA ]:
298.24000

[ LogP ]:
0.31790

[ Vapour Pressure ]:
1.76E-35mmHg at 25°C

[ Index of Refraction ]:
1.854

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Serotonin transporter (5-HTTLPR) and norepinephrine transporter (NET) gene polymorphisms: susceptibility and treatment response of electroconvulsive therapy in treatment resistant depression.

Neurosci. Lett. 590 , 116-20, (2015)

Serotonin transporter (5-HTTLPR) and norepinephrine transporter (NET182C) polymorphisms are associated with susceptibility and treatment response in major depressive disorder (MDD). Thus, we examined ...

5-HTTLPR genotype, asthma, diabetes and late-life depression in an older French population.

Int. J. Geriatr. Psychiatry 30 , 1017-22, (2015)

Associations between environmental risk factors and depression have been reported to be stronger in people with the S allele of the S/L polymorphism in the serotonin transporter gene-linked promoter r...

Clinicopathologic report of ocular involvement in ALS patients with C9orf72 mutation.

Amyotroph. Lateral Scler. Frontotemporal Degener. 15(7-8) , 569-80, (2014)

Our objective was to present clinicopathologic evidence of anterior visual pathway involvement in patients with amyotrophic lateral sclerosis (ALS) secondary to a C9orf72 mutation. Two related patient...