Zacopride hydrochloride

Names

[ Name ]:
Zacopride hydrochloride

[Synonym ]:
4-Amino-N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxybenzami de hydrochloride (1:1)

Biological Activity

[Description]:

Zacopride hydrochloride is a potent antagonist of 5-HT3 receptor with a Ki of 0.38 nM. Zacopride hydrochloride is also a agonist of 5-HT4 receptor with a Ki of 373 nM. Zacopride hydrochloride has anxiolytic activity. Zacopride hydrochloride has the potential for the research of Schizophrenia[1][2][3].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Nagakura Y, et al. Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT4 receptor versus human 5-HT3 receptor. Pharmacol Res. 1999;39(5):375-382.

[2]. Costall B, et al. Zacopride: anxiolytic profile in rodent and primate models of anxiety. J Pharm Pharmacol. 1988;40(4):302-305.

[3]. Newcomer JW, et al. Zacopride in schizophrenia: a single-blind serotonin type 3 antagonist trial. Arch Gen Psychiatry. 1992;49(9):751-752.

Chemical & Physical Properties

[ Melting Point ]:
158-160 °C

[ Molecular Formula ]:
C₁₅H₂₁Cl₂N₃O₂

[ Molecular Weight ]:
346.25200

[ Exact Mass ]:
345.10100

[ PSA ]:
71.08000

[ LogP ]:
3.65070

MSDS

Click to get detail MSDS

Related Compounds

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