AM 4668

Names

[ CAS No. ]:
1011531-27-3

[ Name ]:
AM 4668

[Synonym ]:
(3S)-3-[4-({4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)phenyl]-3-(1,2-oxazol-3-yl)propanoic acid
3-Isoxazolepropanoic acid, β-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl]-, (βS)-

Biological Activity

[Description]:

AM-4668 is a GPR40 agonist for type 2 diabetes. EC50s of 3.6 nM and 36 nM for GPR40 in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), respectively[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GPR40
Research Areas >> Metabolic Disease

[Target]

EC50: 3.6 nM (GPR40, in A9 cells), 36 nM (GPR40, in CHO cells)[1]


[References]

[1]. Liu JJ, et al. Optimization of GPR40 Agonists for Type 2 Diabetes. ACS Med Chem Lett. 2014 Feb 6;5(5):517-21.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
633.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H19F3N2O4S

[ Molecular Weight ]:
488.48

[ Flash Point ]:
336.9±34.3 °C

[ Exact Mass ]:
488.101776

[ LogP ]:
5.27

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.583

Related Compounds