Z433927330

Names

[ Name ]:
Z433927330

Biological Activity

[Description]:

Z433927330 is a potent and selective inhibitor of Aquaporin-7 (AQP7), less potently inhibits AQP3 and AQPs9, with IC50s of ~0.2 µM, ~0.7 µM and ~1.1 µM for mAQP7, mAQP3 and mAQP9, respectively[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

IC50: ~0.2 µM (mAQP7), ~0.7 µM (mAQP3), ~1.1 µM (mAQP9)[1]

[In Vitro]

Z433927330 inhibits glycerol permeability, with an IC50 of ~0.6 µM[1].

[References]

[1]. Z433927330, et al. Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. J Biol Chem. 2019 May 3;294(18):7377-7387.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₀N₄O₃

[ Molecular Weight ]:
364.40

Related Compounds

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