FFN511

Names

[ Name ]:
FFN511

[Synonym ]:
1H,5H,11H-[1]Benzopyrano[6,7,8-ij]quinolizin-11-one, 9-(2-aminoethyl)-2,3,6,7-tetrahydro-
9-(2-Aminoethyl)-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11-one

Biological Activity

[Description]:

FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 µM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Membrane Transporter/Ion Channel >> Monoamine Transporter

[In Vitro]

FFN511 (350 nM; 30 min) accumulats in a pattern consistent with LDCVs in cultured mouse chromaffin cells, and the accumulation is abolished by the lipophilic base chloroquine[1]. Cell Viability Assay[1] Cell Line: mouse chromaffin cells Concentration: 350 nM Incubation Time: 30 min Result: Accumulated in cultured mouse chromaffin cells (the same as LDCVs), and the accumulation could be abolished by the lipophilic base chloroquine, which collapses the vesicle pH gradient.

[References]

[1]. Gubernator NG, et al. Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals. Science. 2009 Jun 12;324(5933):1441-4.

[2]. Keighron JD, et al. Analytical tools to monitor exocytosis: a focus on new fluorescent probes and methods. Analyst. 2012 Apr 21;137(8):1755-63.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
538.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₀N₂O₂

[ Molecular Weight ]:
284.353

[ Flash Point ]:
279.5±30.1 °C

[ Exact Mass ]:
284.152466

[ LogP ]:
3.05

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.658

Related Compounds

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