VUF8430 dihydrobromide

Names

[ Name ]:
VUF8430 dihydrobromide

[Synonym ]:
2-Carbamimidamidoethyl carbamimidothioate dihydrobromide

Biological Activity

[Description]:

VUF 8430 (dihydrobromide) is a potent and selective histamine H4 receptor agonist with a Ki of 31.6 nM and an EC50 of 50 nM[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[References]

[1]. Lim HD, et al. Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. J Med Chem. 2006 Nov 16;49(23):6650-1.

Chemical & Physical Properties

[ Boiling Point ]:
348.8ºC at 760 mmHg

[ Molecular Formula ]:
C₄H₁₃Br₂N₅S

[ Molecular Weight ]:
323.05300

[ Flash Point ]:
164.8ºC

[ Exact Mass ]:
320.92600

[ PSA ]:
137.07000

[ LogP ]:
3.00330

[ Vapour Pressure ]:
4.91E-05mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UM6960000

CHEMICAL NAME :: Pseudourea, 2-(2-guanidinoethyl)-2-thio-, dihydrobromide

CAS REGISTRY NUMBER :: 100130-32-3

LAST UPDATED :: 198806

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C4-H11-N5-S.2Br-H

MOLECULAR WEIGHT :: 323.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RAREAE Radiation Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1954- Volume(issue)/page/year: 7,22,1957

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
UM6960000