<Suppliers Price>

VUF8430 dihydrobromide

Names

[ CAS No. ]:
100130-32-3

[ Name ]:
VUF8430 dihydrobromide

[Synonym ]:
2-Carbamimidamidoethyl carbamimidothioate dihydrobromide

Biological Activity

[Description]:

VUF 8430 (dihydrobromide) is a potent and selective histamine H4 receptor agonist with a Ki of 31.6 nM and an EC50 of 50 nM[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[References]

[1]. Lim HD, et al. Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. J Med Chem. 2006 Nov 16;49(23):6650-1. 

Chemical & Physical Properties

[ Boiling Point ]:
348.8ºC at 760 mmHg

[ Molecular Formula ]:
C4H13Br2N5S

[ Molecular Weight ]:
323.05300

[ Flash Point ]:
164.8ºC

[ Exact Mass ]:
320.92600

[ PSA ]:
137.07000

[ LogP ]:
3.00330

[ Vapour Pressure ]:
4.91E-05mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UM6960000
CHEMICAL NAME :
Pseudourea, 2-(2-guanidinoethyl)-2-thio-, dihydrobromide
CAS REGISTRY NUMBER :
100130-32-3
LAST UPDATED :
198806
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C4-H11-N5-S.2Br-H
MOLECULAR WEIGHT :
323.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RAREAE Radiation Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1954- Volume(issue)/page/year: 7,22,1957

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
UM6960000

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.