Landipirdine

Names

[ Name ]:
Landipirdine

[Synonym ]:
1-({(1R)-6-[(3-Fluorophenyl)sulfonyl]-1,2,3,4-tetrahydro-1-naphthalenyl}methyl)urea
Landipirdine
UNII:J0NX985GDI
J0NX985GDI
N-{[(1R)-6-(3-fluorobenzenesulfonyl)-1,2,3,4-tetrahydronaphthalen-1- yl]methyl}urea
RO5025181
SYN120
Urea, N-[[(1R)-6-[(3-fluorophenyl)sulfonyl]-1,2,3,4-tetrahydro-1-naphthalenyl]methyl]-
10424
RO5025181-000

Biological Activity

[Description]:

Landipirdine is a selective antagonist of 5-HT6R. Landipirdine has great effect on the hERG pharmacophore[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Harris RN 3rd, et al. Highly potent, non-basic 5-HT6 ligands. Site mutagenesis evidence for a second binding mode at 5-HT6 for antagonism. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3436-40.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
564.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₉FN₂O₃S

[ Molecular Weight ]:
362.42

[ Flash Point ]:
295.3±30.1 °C

[ Exact Mass ]:
362.110046

[ LogP ]:
2.63

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.593