[The effect of irradiation and alkylating agents on chromatin breakdown in normal and malignant lymphoid cells].

N I Riabchenko, V Jurasková, B P Ivannik, A V Konov, V Drasil

Index: Radiobiologiia 31(1) , 22-6, (1991)

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Abstract

Regularities of chromatin degradation in thymocytes and LS/BL tumor cells have been investigated. It has been shown that the rate of DNA degradation by Ca/Mg-dependent endonuclease in LS/BL tumor cells is 25 times lower than that in thymocytes, and radiation does not induce chromatin degradation. The alkylating agent TS 160 causes chromatin degradation in both LS/BL cells and thymocytes. In contrast to radiation TS 160 inhibits the endogenous chromatin degradation by Ca/Mg-dependent endonuclease in thymocytes.