The effects of radiation and alkylating agents on chromatin degradation in normal and tumour lymphoid cells.

N I Ryabchenko, V Jurásková, B P Ivannik, A V Konov, V Drásil

Index: Gen. Physiol. Biophys. 10(1) , 41-8, (1991)

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Abstract

The dynamic of chromatin degradation was studied in thymocytes and LS/BL tumour cells. In permeabilised LS/BL cells, the rate of DNA degradation induced by endogenous calcium and magnesium-dependent endonuclease was approx. 25 times slower than in thymocytes. In LS/BL cells irradiation does not induce chromatin degradation. The alkylating agent TS 160 induced chromatin degradation in both LS/BL lymphosarcoma cells and thymocytes.