Journal of Organic Chemistry 2012-05-04

A copper-catalyzed Petasis reaction for the synthesis of tertiary amines and amino esters.

Robin Frauenlob, Carlos García, Gary A Bradshaw, Helen M Burke, Enda Bergin

Index: J. Org. Chem. 9th ed., 77 , 4445-4449, (2012)

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Abstract

We have developed a copper-catalyzed process for the coupling of aldehydes, amines, and boronic acids. This allows greater reactivity with simple aryl boronic acids and allows coupling reactions to proceed that previously failed. Initial mechanistic studies support a process involving transmetalation from boron to copper.

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