Cationic palladium(II)-catalyzed addition of arylboronic acids to nitriles. One-step synthesis of benzofurans from phenoxyacetonitriles.

Baowei Zhao, Xiyan Lu

Index: Org. Lett. 8 , 5987, (2006)

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Abstract

[Structure: see text] A cationic palladium complex catalyzed addition of arylboronic acids to nitriles to yield aryl ketones with moderate to good yields was developed. A one-step synthesis of benzofurans from phenoxyacetonitriles under the catalysis of [(bpy)Pd+(micro-OH)]2(-OTf)2 or [(bpy)Pd2+(H2O)2](-OTf)2 was developed which showed that the cationic palladium catalyst is highly active for these addition reactions.