Journal of Organic Chemistry 2003-06-13

Efficient and practical method for synthesizing optically active indan-2-ols by the Ti(O-i-Pr)(4)/2 i-PrMgCl-mediated metalative Reppe reaction.

Takeshi Hanazawa, Kousuke Sasaki, Yuuki Takayama, Fumie Sato

Index: J. Org. Chem. 68(12) , 4980-3, (2003)

Full Text: HTML

Abstract

An efficient and practical synthesis of optically active indan-2-ols 1 has been developed starting from readily accessible optically active 4-siloxy-1,6-alkadiynes 2 and ethynyl p-tolyl sulfone, where the metalative Reppe reaction mediated by an economical divalent titanium reagent, Ti(O-i-Pr)(4)/2 i-PrMgCl, is a key step.

Related Compounds

Related Articles:

Tosvinyl and besvinyl as protecting groups of imides, azinones, nucleosides, sultams, and lactams. Catalytic conjugate additions to tosylacetylene.

2014-09-19

[J. Org. Chem. 79(18) , 8826-34, (2014)]

A Simplified Method for the Preparation of Ethynyl P-Tolyl Sulfone and Ethynyl Phenyl Sulfone. Chen Z and Trudell ML.

[Synth. Commun. 24(21) , 3149-55, (1994)]

Design and synthesis of beta-methoxyacrylate analogues via click chemistry and biological evaluations.

2007-04-01

[Bioorg. Med. Chem. Lett. 17 , 1979-83, (2007)]

More Articles...