Installation of protected ammonia equivalents onto aromatic & heteroaromatic rings in water enabled by micellar catalysis

NA Isley, S Dobarco, BH Lipshutz

Index: Isley, Nicholas A.; Dobarco, Sebastian; Lipshutz, Bruce H. Green Chemistry, 2014 , vol. 16, # 3 p. 1480 - 1488

Full Text: HTML

Citation Number: 12

Abstract

A single set of conditions consisting of a palladium catalyst, a commercially available ligand, and a base, allow for several types of C–N bond constructions to be conducted in water with the aid of a commercially available “designer” surfactant (TPGS-750-M). Products containing a protected NH 2 group in the form of a carbamate, sulfonamide, or urea can be fashioned starting with aryl or heteroaryl bromides, iodides, and in some cases, chlorides, as ...