A direct synthesis of pyrrolocytosine from 5-iodocytosine.
R H E Hudson, A K Dambenieks, R D Viirre
Index: Nucleosides Nucleotides Nucleic Acids 24 , 581-584, (2005)
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Abstract
We have employed a tandem Sonogashira/annulation reaction between 5-iodocytosine derivatives and terminal alkynes to yield the fluorescent bicyclic nucleobase pyrrolcytosine. Pyrrolocytosine bearing substituents only on the pyrrole ring are conveniently synthesized from 5-iodocytosine. Water soluble pyrrolocytosines are being investigated as reporter groups in SNP analysis.
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