A convenient synthesis of 2-(alkylamino) pyridines
DM Krein, TL Lowary
Index: Krein, Douglas M.; Lowary, Todd L. Journal of Organic Chemistry, 2002 , vol. 67, # 14 p. 4965 - 4967
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Citation Number: 33
Abstract
The asymmetric reduction of prochiral ketones by a complex formed from lithium aluminum hydride, (1R,2S)-(−)-N-methylephedrine, and 2-(ethylamino)pyridine (1a, Chart 1) is a useful method for the synthesis of optically pure secondary alcohols. 1,2 In the course of other investigations, we had the need to carry out this reduction on large scale and thus required significant quantities of 1a. ... When choosing among the methods reported for the preparation of ...
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