Regiospecific solid-phase strategy to N7-substituted purines and its application to 8-azapurines and [I]-condensed purines.

Han Fu, Mark Kheng Chuan Tan, Yulin Lam

Index: J. Comb. Chem. 9(5) , 804-10, (2007)

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Abstract

A highly regioselective and traceless solid-phase route to 1,7,8-trisubstituted purines has been developed. This methodology could be extended to the preparation of 8-azapurines and [i]-condensed purines. A representative set of 17 purines, azapurines, and [i]-condensed purines was synthesized. This paper also describes a mild method to prepare the p-benzyloxybenzylamine (BOBA) resin.