Bioorganic & Medicinal Chemistry Letters 2001-07-09

Novel sulfonate derivatives: potent antimitotic agents.

S L Gwaltney, H M Imade, Q Li, L Gehrke, R B Credo, R B Warner, J Y Lee, P Kovar, D Frost, S C Ng, H L Sham

Index: Bioorg. Med. Chem. Lett. 11(13) , 1671-3, (2001)

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Abstract

The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported. Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.