Human somatostatin receptor specificity of backbone-cyclic analogues containing novel sulfur building units

…, O Karpov, P Litman, M Bracha, M Afargan…

Index: Gazal, Sharon; Gelerman, Garry; Ziv, Ofer; Karpov, Olga; Litman, Pninit; Bracha, Moshe; Afargan, Michel; Gilon, Chaim Journal of Medicinal Chemistry, 2002 , vol. 45, # 8 p. 1665 - 1671

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Citation Number: 46

Abstract

Somatostatin-14 (somatostatin) and its clinically available analogues octreotide, lanreotide, and vapreotide are potent inhibitors of growth hormone, insulin, and glucagon release. Recently, a novel backbone cyclic somatostatin analogue c (GABA-Phe-Trp-(D) Trp-Lys-Thr- Phe-GlyC3-NH2)(analogue 1, PTR 3173) that possesses in vivo endocrine selectivity was described. This long-acting octapeptide exhibits high affinity to human recombinant ...