Thalidomide derivatives for the treatment of neuroinflammation

C Contino??Pépin, A Parat, C Patinote…

Index: Contino-Pepin, Christiane; Parat, Audrey; Patinote, Cindy; Roscoe, Wendi A.; Karlik, Stephen J.; Pucci, Bernard ChemMedChem, 2010 , vol. 5, # 12 p. 2057 - 2064

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Citation Number: 6

Abstract

Abstract The precise mechanism-of-action of thalidomide remains uncertain and might differ between diseases and under different clinical condition. With implications in the treatment of a variety of inflammatory and autoimmune diseases, as well as for use as an anticancer agent, alone or in combination with established therapeutics, it is clear that thalidomide and its derivatives deserve further scrutiny. In particular, thalidomide was shown to be effective ...