Central and peripheral anti-inflammatory effects of maprotiline on carrageenan-induced paw edema in rats.

V Hajhashemi, H Sadeghi, M Minaiyan, A Movahedian, A Talebi

Index: Inflamm. Res. 59(12) , 1053-9, (2010)

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Abstract

To explore the site of action of maprotiline, as an atypical antidepressant, on carrageenan-induced paw edema.Male Wistar rats were used.Firstly, the anti-inflammatory effect of systemic maprotiline (12.5, 25 and 50 mg kg(-1)) was assessed using a paw edema model. Secondly, different doses of maprotiline were administrated intracerebroventricularly, intrathecally and locally before carrageenan challenge. Finally, we tried to reverse the anti-inflammatory effect of maprotiline by propranolol (10 mg kg(-1)), prazosin (4 mg kg(-1)), yohimbine (10 mg kg(-1)), naloxone (4 mg kg(-1)) and mifepristone (5 mg kg(-1)).Systemic, intracerebroventricular and subplantar application of maprotiline significantly inhibited peripheral edema, but intrathecal maprotiline did not alter the degree of paw swelling. The applied antagonists failed to change the anti-inflammatory activity of maprotiline.These results demonstrate that maprotiline has a potent anti-inflammatory effect and this effect is linked to the peripheral and supraspinal actions of the drug.