Rapid purification of small molecule libraries by ion exchange chromatography
…, BA Dressman, JE Fritz, JR Grunwell, SW Kaldor
Index: Siegel, Miles G.; Hahn, Patric J.; Dressman, Bruce A.; Fritz, James E.; Grunwell, Jocelyn R.; Kaldor, Stephen W. Tetrahedron Letters, 1997 , vol. 38, # 19 p. 3357 - 3360
Full Text: HTML
Citation Number: 139
Abstract
Amines and acylated amines are synthesized in traditional solution phase reactions, then rapidly purified by ion exchange chromatography to yield pure products. In some instances, impurities devoid of ionizable functionality can be covalently modified prior to purification. The generic purification sequence is applicable to a variety of reactions, and is amenable to automation with commercially available equipment.
Related Articles:
[Kwon, Min Serk; Kim, Sungjin; Park, Sungho; Bosco, William; Chidrala, Ravi Kumar; Park, Jaiwook Journal of Organic Chemistry, 2009 , vol. 74, # 7 p. 2877 - 2879]
[Horrillo-Martinez, Patricia; Hultzsch, Kai C.; Gil, Adria; Branchadell, Vicenc European Journal of Organic Chemistry, 2007 , # 20 p. 3311 - 3325]
[Fukuyama, Tohru; Cheung, Mui; Jow, Chung-Kuang; Hidai, Yuko; Kan, Toshiyuki Tetrahedron Letters, 1997 , vol. 38, # 33 p. 5831 - 5834]
[Hamana, Hiroshi; Iwasaki, Fuminori; Nagashima, Hiroyoshi; Hattori, Kazuhisa; Hagiwara, Tokio; Narita, Tadashi Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 4 p. 1109 - 1113]