Base??Catalyzed Anti??Markovnikov Hydroamination of Vinylarenes–Scope, Limitations and Computational Studies
P Horrillo??Martínez, KC Hultzsch, A Gil…
Index: Horrillo-Martinez, Patricia; Hultzsch, Kai C.; Gil, Adria; Branchadell, Vicenc European Journal of Organic Chemistry, 2007 , # 20 p. 3311 - 3325
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Citation Number: 33
Abstract
Abstract The hydroamination of vinylarenes with primary and secondary amines was studied with catalytic amounts as low as 2 mol-% of LiN (SiMe 3) 2/TMEDA. Reactions proceeded readily at 120 C in the absence of solvent to give selective anti-Markovnikov addition. Slow addition was observed at 25 C with either electron-deficient p-chlorostyrene or secondary cyclic amines such as pyrrolidine, piperidine, or morpholine. Primary amines were prone ...
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