Tetrahedron

Regioselective synthesis of flavone derivatives via DMAP-catalyzed cyclization of o-alkynoylphenols

M Yoshida, Y Fujino, K Saito, T Doi

Index: Yoshida, Masahito; Fujino, Yuta; Saito, Koya; Doi, Takayuki Tetrahedron, 2011 , vol. 67, # 51 p. 9993 - 9997

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Citation Number: 30

Abstract

A catalytic amount of DMAP promoted cyclization of o-alkynoylphenols via a 6-endo cyclization mode leading to flavone derivatives in high yields without forming 5-exo cyclized aurone derivatives. Utilizing this method, methoxy substituted flavone and alkyl substituted γ- benzopyranone derivatives were synthesized.

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