Ferrocenyl flavonoid-induced morphological modifications of endothelial cells and cytotoxicity against B16 murine melanoma cells

…, L Quentin, P Pigeon, G Jaouen, A Vessières…

Index: Monserrat, Jean-Philippe; Tiwari, Keshri Nath; Quentin, Lionel; Pigeon, Pascal; Jaouen, Gerard; Vessieres, Anne; Chabot, Guy G.; Hillard, Elizabeth A. Journal of Organometallic Chemistry, 2013 , vol. 734, p. 78 - 85

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Citation Number: 11

Abstract

With the aim of improving the cytotoxic and vascular disrupting activities of flavonoids, several classes of ferrocenyl-modified flavonoids were prepared and tested on cancer and endothelial cells. Three ten-member series of ferrocenyl flavonoids: chalcones ((E)-1-(R-2′- hydroxyphenyl)-3-ferrocenylprop-2-en-1-ones), aurones ((Z)-R-2-(ferrocenylidene) benzofuran-3-ones) and flavones (R-2-ferrocenyl-chromen-4-ones) were synthesized by ...