Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways

Baolei Zhao, Yong Ma, Zhilin Xu, Jizhou Wang, Fengjun Wang, Dawei Wang, Shangha Pan, Yaohua Wu, Huayang Pan, Dongsheng Xu, Lianxin Liu, Hongchi Jiang

Index: Cancer Lett. 347(1) , 79-87, (2014)

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Abstract

The present study aimed to investigate the anti-cancer effects of hydroxytyrosol (HT) in human hepatocellular carcinoma (HCC) cells. Our results show that HT could inhibit proliferation, induce G2/M cell cycle arrest and apoptosis in human HCC cells. Mechanically, we found that HT could suppress the activation of AKT and nuclear factor-kappa B (NF-κB) pathways. HT also significantly inhibited the tumor growth, angiogenesis and the activation of AKT and NF-κB pathways in an orthotopic model of human HCC in vivo. These data suggest that HT may be a promising candidate agent for the treatment of HCC.