Bioorganic & Medicinal Chemistry Letters 2009-08-01

Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.

Terance Hart, Alba T Macias, Karen Benwell, Teresa Brooks, Jalanie D'Alessandro, Pawel Dokurno, Geraint Francis, Ben Gibbons, Timothy Haymes, Guy Kennett, Sean Lightowler, Howard Mansell, Natalia Matassova, Anil Misra, Anthony Padfield, Rachel Parsons, Robert Pratt, Alan Robertson, Steven Walls, Melanie Wong, Stephen Roughley

Index: Bioorg. Med. Chem. Lett. 19(15) , 4241-4, (2009)

Full Text: HTML

Abstract

We report the discovery of a novel, chiral azetidine urea inhibitor of Fatty Acid Amide Hydrolase (FAAH,) and describe the surprising species selectivity of VER-156084 versus rat and human FAAH and also hCB1.

Related Compounds

Related Articles:

Synthesis from D-altrose of (5R,6R,7R,8S)-5,7-dihydroxy-8-hydroxymethylconidine and 2,4-dideoxy-2,4-imino-D-glucitol, azetidine analogues of swainsonine and 1,4-dideoxy-1,4-imino-D-mannitol.

2012-08-17

[Org. Lett. 14(16) , 4174-7, (2012)]

Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor.

2012-07-01

[Bioorg. Med. Chem. Lett. 22(13) , 4281-7, (2012)]

Complex N-heterocycle synthesis via iron-catalyzed, direct C-H bond amination.

2013-05-03

[Science 340(6132) , 591-5, (2013)]

Chemistry and pharmacology of nicotinic ligands based on 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for possible use in depression.

2009-08-01

[ChemMedChem 4(8) , 1279-91, (2009)]

A theoretical study of dihydrogen bonds in small protonated rings: aziridine and azetidine cations.

2010-02-01

[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 75(2) , 563-6, (2010)]

More Articles...