Azetidine

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
64.9±8.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃H₇N

[ Molecular Weight ]:
57.094

[ Flash Point ]:
-23.6±16.5 °C

[ Exact Mass ]:
57.057850

[ PSA ]:
12.03000

[ LogP ]:
-0.20

[ Vapour Pressure ]:
161.5±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.426

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
miscible

Click to get detail MSDS

[ Symbol ]:

GHS02, GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H314

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
F: Flammable;C: Corrosive;

[ Risk Phrases ]:
R11;R34

[ Safety Phrases ]:
S16-S26-S36/37/39-S45

[ RIDADR ]:
UN 2733 3/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
I

[ Hazard Class ]:
3.1

[ HS Code ]:
29339990

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synthesis from D-altrose of (5R,6R,7R,8S)-5,7-dihydroxy-8-hydroxymethylconidine and 2,4-dideoxy-2,4-imino-D-glucitol, azetidine analogues of swainsonine and 1,4-dideoxy-1,4-imino-D-mannitol.

Org. Lett. 14(16) , 4174-7, (2012)

Ring closure of a 3,5-di-O-triflate derived from D-altrose with benzylamine allowed the formation of both monocyclic and bicyclic azetidine analogues of swainsonine.

Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor.

Bioorg. Med. Chem. Lett. 22(13) , 4281-7, (2012)

The discovery of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor is described. The characterization and redressing of the issues associated with these compounds is detailed. ...

Complex N-heterocycle synthesis via iron-catalyzed, direct C-H bond amination.

Science 340(6132) , 591-5, (2013)

The manipulation of traditionally unreactive functional groups is of paramount importance in modern chemical synthesis. We have developed an iron-dipyrrinato catalyst that leverages the reactivity of ...

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