First synthesis of 3-aryl-4-unsubstituted-6-CF(3)-pyridin-2-ones via aryl migration reaction in the presence of PhI(OAc)(2)/NaOH.
Hai Yi, Liping Song, Wei Wang, Jianning Liu, Shizheng Zhu, Hongmei Deng, Min Shao
Index: Chem. Commun. (Camb.) 46(37) , 6941-3, (2010)
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Abstract
3-Aryl-4-unsubstituted-6-CF(3)-pyridin-2-ones have been efficiently synthesized from readily available 4-aryl-3-carbamoyl-6-CF(3)-pyridin-2(1H)-ones by treatment with PhI(OAc)(2) in the presence of NaOH.
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