Synthesis of benzimidazoles by PIDA-promoted direct C(sp2)-H imidation of N-arylamidines.
Jinbo Huang, Yimiao He, Yong Wang, Qiang Zhu
Index: Chemistry 18(44) , 13964-7, (2012)
Full Text: HTML
Abstract
A metal-free synthesis of diversified benzimidazoles from N-arylamidines through a phenyliodine(III) diacetate (PIDA) promoted intramolecular direct C(sp(2))-H imidation has been developed. The reaction proceeds smoothly at 0 °C or ambient temperature to provide the desired products in good to excellent yields. The synthesis of 2-alkyl- or 2-alkyl-fused benzimidazoles, which are generally inaccessible by similar Pd- or Cu-catalyzed approaches, can also be achieved.Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Related Compounds
Related Articles:
2010-04-02
[Org. Lett. 12(7) , 1552-5, (2010)]
Palladium-catalyzed oxygenation of unactivated sp3 C-H bonds.
2004-08-11
[J. Am. Chem. Soc. 126 , 9542-9543, (2004)]
Determination of vitamin C in tablets and fruits by titration with phenyliodosoacetate.
1982-01-01
[Il Farmaco 37(1) , 9-14, (1982)]
Copper-catalyzed diacetoxylation of olefins using PhI(OAc)2 as oxidant.
2010-04-02
[Org. Lett. 12(7) , 1412-5, (2010)]
2000-04-20
[J. Med. Chem. 43(8) , 1550-62, (2000)]